Job Syndrome

Important

It is possible that the main title of the report Job Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

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• HIE Syndrome
• Hyper-IgE Syndrome
• Hyperimmunoglobulin E Syndrome
• Hyperimmunoglobulin E-Recurrent Infection Syndrome
• Hyperimmunoglobulinemia E-Staphylococcal
• Job-Buckley Syndrome

Disorder Subdivisions

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• None

General Discussion

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Job Syndrome is an immunodeficiency syndrome characterized by recurrent bacterial (staphylococcal) infections, particularly of the skin, and markedly elevated IgE [Immunoglobulin E] levels.



Some patients have an autosomal dominant inheritance. The staphylococcal infection may involve the skin, lungs, joints and other sites. Some patients have coarse features; some are fair and redheaded. Decreased bone density and frequent fractures are common. Some present with neutrophils (a particular white blood cell) that don't function normally. Signs of allergy, e. g. eczema, asthma and/or runny noses, are sometimes present as well. Treatment consists of intermittent or continuous antibiotics.

Resources

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March of Dimes Birth Defects Foundation

1275 Mamaroneck Avenue

White Plains, NY 10605

Tel: (914)428-7100

Fax: (914)997-4763

Tel: (888)663-4637

Email: Askus@marchofdimes.com

Internet: http://www.marchofdimes.com



Immune Deficiency Foundation

40 West Chesapeake Avenue

Suite 308

Towson, MD 21230

Tel: (410)321-6647

Fax: (410)321-9165

Tel: (800)296-4433

Email: idf@primaryimmune.org

Internet: http://www.primaryimmune.org



NIH/National Institute of Allergy and Infectious Diseases

6610 Rockledge Drive

MSC 6612

Bethesda, MD 20892-6612

Tel: (301)496-5717

Fax: (301)402-3573

TDD: (800)877-8339

Internet: http://www.niaid.nih.gov/



International Patient Organization for Primary Immunodeficiencies

Firside

Main Road

Downderry

Cornwall, PL11 3LE

United Kingdom

Tel: 44 1503 250 668

Fax: 44 1503 250 668

Email: info@ipopi.org

Internet: http://www.ipopi.org/

For a Complete Report

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This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:   8/8/2007

Copyright   1991, 1999, 2007 National Organization for Rare Disorders, Inc.