Who is affected by Tay-Sachs disease


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Who is affected by Tay-Sachs disease


Tay-Sachs disease occurs most often in people of Ashkenazi Jewish descent. About 1 out of 30 people in this population is a carrier of the disease (has the Tay-Sachs trait).1, 2 People of French-Canadian descent from the East Saint Lawrence River Valley of Quebec and people of Cajun descent in Louisiana are also at a higher risk than the general population.

In North America, about 3 to 5 babies are born each year with Tay-Sachs disease among the Ashkenazi Jewish population.1 For more information on genetic tests for people of Ashkenazi Jewish descent, see the topic Ashkenazi Jewish Genetic Panel (AJGP).

References


Citations

  1. Vallance H, Ford J (2003). Carrier testing for autosomal-recessive disorders. Clinical Laboratory Sciences, 40(4): 473–497.

  2. Committee on Genetics, American College of Obstetricians and Gynecologists (2004). Prenatal and preconceptional carrier screening for genetic diseases in individuals of Eastern European Jewish descent. Obstetrics and Gynecology, 104(2): 425–428.

Credits


Author Sabra L. Katz-Wise
Editor Susan Van Houten, RN, BSN, MBA
Associate Editor Tracy Landauer
Associate Editor Pat Truman
Primary Medical Reviewer Michael J. Sexton, MD

- Pediatrics
Specialist Medical Reviewer Renee H. Martin, PhD

- Medical Genetics
Last Updated April 14, 2006

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Last updated: April 14, 2006
Author: Sabra L. Katz-Wise
Reviewed By: Michael J. Sexton, MD - Pediatrics, Renee H. Martin, PhD - Medical Genetics
Editors: Susan Van Houten, RN, BSN, MBA, Pat Truman

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